Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 3.690


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GABPAchr21_+_271077310.531.8e-01Click!
ELK4chr1_-_2056019990.472.4e-01Click!
ELK1chrX_-_475099930.413.2e-01Click!
GABPB1chr15_-_506473850.393.4e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_15872905 3.259


chrX_-_15872921 3.234 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_22351984 2.707 LINC00339
long intergenic non-protein coding RNA 339
chrX_-_15872882 2.638 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_180650233 2.520 NM_033549
NM_201627
TRIM41

tripartite motif containing 41

chr2_+_109745996 2.505 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr5_+_180650274 2.449 TRIM41
tripartite motif containing 41
chrX_-_106959597 2.305 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr13_-_33760215 2.266 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chrX_-_153775774 2.200 NM_001042351
G6PD
glucose-6-phosphate dehydrogenase
chr5_+_180650709 2.181 TRIM41
tripartite motif containing 41
chr6_+_30524662 2.177 PRR3
proline rich 3
chrX_-_153775427 2.143 G6PD
glucose-6-phosphate dehydrogenase
chr12_-_105629790 2.121 NM_001251904
NM_018171
APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chrX_-_15872938 2.120 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_46722139 2.084 ARHGAP1
Rho GTPase activating protein 1
chrX_-_15872871 2.013 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_38034357 2.006 BAG4
BCL2-associated athanogene 4
chr9_-_88969256 1.988 ZCCHC6
zinc finger, CCHC domain containing 6
chr10_-_1102643 1.979 IDI1
isopentenyl-diphosphate delta isomerase 1
chr1_-_28969516 1.931 NM_001135218
NM_005644
TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr1_+_162467622 1.897 UHMK1
U2AF homology motif (UHM) kinase 1
chrX_-_106960028 1.881 TSC22D3
TSC22 domain family, member 3
chr6_+_30525050 1.836 PRR3
proline rich 3
chr12_+_53443834 1.803 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr14_+_52327384 1.790 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr1_+_26146446 1.765 FAM54B
family with sequence similarity 54, member B
chr16_-_67260720 1.764 NM_012163
LRRC29
leucine rich repeat containing 29
chr2_+_65454828 1.751 NM_001005386
NM_005722
ACTR2

ARP2 actin-related protein 2 homolog (yeast)

chr3_+_20081853 1.739 KAT2B
K(lysine) acetyltransferase 2B
chr17_-_42264075 1.739 NM_178542
C17orf65
chromosome 17 open reading frame 65
chr17_-_42264023 1.728 C17orf65
chromosome 17 open reading frame 65
chr1_+_26146376 1.691 NM_001099625
NM_001099627
FAM54B

family with sequence similarity 54, member B

chr1_+_26146622 1.687 NM_019557
FAM54B
family with sequence similarity 54, member B
chr12_-_48499840 1.642 SENP1
SUMO1/sentrin specific peptidase 1
chr22_+_22020272 1.627 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr2_+_175260455 1.610 NM_001193528
NM_024583
SCRN3

secernin 3

chr11_+_6502607 1.609 NM_012192
FXC1
fracture callus 1 homolog (rat)
chr11_-_46722160 1.607 ARHGAP1
Rho GTPase activating protein 1
chr15_-_89089792 1.580 NM_001144074
NM_017996
DET1

de-etiolated homolog 1 (Arabidopsis)

chr12_+_120105656 1.578 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr5_+_95066628 1.577 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr2_-_153032141 1.564 NM_005843
STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr15_-_75135479 1.554 ULK3
unc-51-like kinase 3 (C. elegans)
chr1_-_1590403 1.547 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chrX_-_15873094 1.515 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr15_-_75135480 1.512 ULK3
unc-51-like kinase 3 (C. elegans)
chr20_+_49575347 1.488 NM_014484
MOCS3
molybdenum cofactor synthesis 3
chr15_-_75135524 1.471 NM_001099436
ULK3
unc-51-like kinase 3 (C. elegans)
chr10_+_1102741 1.468 NM_014023
WDR37
WD repeat domain 37
chr1_+_162467635 1.433 UHMK1
U2AF homology motif (UHM) kinase 1
chr14_+_100842728 1.419 NM_001161476
NM_024515
WDR25

WD repeat domain 25

chr14_+_74003817 1.400 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr7_+_2281856 1.400 NM_002452
NM_198948
NM_198949
NM_198950
NM_198952
NUDT1




nudix (nucleoside diphosphate linked moiety X)-type motif 1




chr5_+_95067511 1.399


chr1_+_222988324 1.380 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr7_+_142552547 1.377 NM_004445
EPHB6
EPH receptor B6
chr16_+_20817766 1.377 NM_001144924
NM_001199053
NM_030941
LOC81691


exonuclease NEF-sp


chr11_+_65769956 1.358 BANF1
barrier to autointegration factor 1
chr21_-_34100210 1.353 SYNJ1
synaptojanin 1
chr14_+_74035865 1.347 ACOT2
acyl-CoA thioesterase 2
chr5_-_137090049 1.316


chr14_-_75593623 1.308 NEK9
NIMA (never in mitosis gene a)- related kinase 9
chr5_-_107717072 1.299 FBXL17
F-box and leucine-rich repeat protein 17
chr14_-_53619820 1.292 DDHD1
DDHD domain containing 1
chr16_+_20818010 1.276 LOC81691
exonuclease NEF-sp
chr16_-_70285794 1.276 NM_058219
EXOSC6
exosome component 6
chrX_+_153775828 1.271 IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chrX_+_153775855 1.271 IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr4_-_107957452 1.269 NM_014421
DKK2
dickkopf 2 homolog (Xenopus laevis)
chr2_-_188419185 1.265 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr3_+_20081523 1.256 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr16_-_31085503 1.250 NM_024706
ZNF668
zinc finger protein 668
chr19_+_17326196 1.232 USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr12_+_94071150 1.231 NM_003805
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr10_-_50747038 1.222 ERCC6
excision repair cross-complementing rodent repair deficiency, complementation group 6
chr2_+_27805892 1.216 NM_032434
ZNF512
zinc finger protein 512
chr6_+_33359312 1.210 NM_002263
KIFC1
kinesin family member C1
chr2_-_238322815 1.208 COL6A3
collagen, type VI, alpha 3
chr14_+_52327021 1.201 NM_001243773
NM_001243774
NM_053064
GNG2


guanine nucleotide binding protein (G protein), gamma 2


chr2_-_27294491 1.197 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr5_+_71403040 1.193 NM_005909
MAP1B
microtubule-associated protein 1B
chr7_+_44084317 1.188 DBNL
drebrin-like
chr5_+_140071220 1.183 HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr7_+_100273776 1.179 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr15_-_75135429 1.176 ULK3
unc-51-like kinase 3 (C. elegans)
chr16_+_23568833 1.176 NM_019116
UBFD1
ubiquitin family domain containing 1
chr5_+_158690265 1.176 UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr1_-_1310553 1.172 NM_001127230
NM_001127229
AURKAIP1

aurora kinase A interacting protein 1

chr3_+_52321853 1.164 GLYCTK
glycerate kinase
chr4_+_153701113 1.159 ARFIP1
ADP-ribosylation factor interacting protein 1
chr1_+_109102970 1.157 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr5_+_87564729 1.154 LOC100505894
uncharacterized LOC100505894
chr22_-_19418998 1.153 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr6_-_52441714 1.149 TRAM2
translocation associated membrane protein 2
chr2_+_175260505 1.147 SCRN3
secernin 3
chr13_+_76210449 1.140 LMO7
LIM domain 7
chr19_+_17326154 1.131 NM_018467
USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr20_+_62612464 1.129 PRPF6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
chrX_+_153775561 1.123 NM_001099857
NM_001145255
IKBKG

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

chr6_-_30585024 1.121 PPP1R10
protein phosphatase 1, regulatory subunit 10
chr14_-_75593720 1.116 NM_033116
NEK9
NIMA (never in mitosis gene a)- related kinase 9
chr20_+_62612403 1.114 NM_012469
PRPF6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
chr3_+_52321835 1.109 NM_001144951
NM_145262
GLYCTK

glycerate kinase

chr16_-_3355374 1.102 NM_033208
TIGD7
tigger transposable element derived 7
chr2_-_188419049 1.096 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr8_-_77912296 1.095 NM_000318
NM_001079867
PEX2

peroxisomal biogenesis factor 2

chr18_+_51795848 1.080 NM_007195
POLI
polymerase (DNA directed) iota
chr21_-_38639593 1.077 DSCR3
Down syndrome critical region gene 3
chr2_-_238322840 1.074 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chrX_-_153775002 1.072 G6PD
glucose-6-phosphate dehydrogenase
chr15_-_71184611 1.062 NM_020147
THAP10
THAP domain containing 10
chr20_+_62612576 1.058


chr22_-_19419215 1.054 NM_003325
HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr5_-_172755418 1.050 STC2
stanniocalcin 2
chr5_-_139937022 1.045 NM_001253764
SRA1
steroid receptor RNA activator 1
chrX_+_51546154 1.043 NM_001005332
MAGED1
melanoma antigen family D, 1
chr20_+_62612493 1.042 PRPF6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
chr1_-_1310817 1.037 NM_017900
AURKAIP1
aurora kinase A interacting protein 1
chr9_+_131133637 1.034 URM1
ubiquitin related modifier 1
chr3_+_151986731 1.034 MBNL1
muscleblind-like (Drosophila)
chrX_+_16964730 1.033 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr2_+_28113598 1.029 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr5_-_172756505 1.027 NM_003714
STC2
stanniocalcin 2
chr2_-_239148545 1.025 HES6
hairy and enhancer of split 6 (Drosophila)
chr7_+_35840595 1.023 NM_001011553
NM_001242956
NM_001788
SEPT7


septin 7


chr5_-_137090033 1.023 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr5_+_173315313 1.012 NM_030627
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr22_-_19419177 1.007 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr10_+_93558281 1.007 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr2_+_74154015 1.004 DGUOK
deoxyguanosine kinase
chrX_+_70586113 1.004 NM_004606
NM_138923
TAF1

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

chr1_+_114472438 1.004 HIPK1
homeodomain interacting protein kinase 1
chr3_-_196669373 1.001 NM_001042540
NM_007362
NCBP2

nuclear cap binding protein subunit 2, 20kDa

chr5_-_176730659 0.992 NM_001031677
NM_130781
RAB24

RAB24, member RAS oncogene family

chr19_+_51226593 0.992 NM_002975
CLEC11A
C-type lectin domain family 11, member A
chr9_+_131218402 0.989 ODF2
outer dense fiber of sperm tails 2
chr1_+_36396673 0.988 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr6_+_33359624 0.986 KIFC1
kinesin family member C1
chr20_-_34287043 0.978 NM_001198989
NM_021100
NFS1

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

chr22_+_47158517 0.977 NM_014346
TBC1D22A
TBC1 domain family, member 22A
chr16_+_2880172 0.973 NM_145252
ZG16B
zymogen granule protein 16 homolog B (rat)
chr5_+_147763560 0.972 FBXO38
F-box protein 38
chr4_-_140005344 0.967 ELF2
E74-like factor 2 (ets domain transcription factor)
chr2_-_238322770 0.966 COL6A3
collagen, type VI, alpha 3
chr5_+_137801166 0.965 EGR1
early growth response 1
chr12_-_56320895 0.965 NM_001143853
WIBG
within bgcn homolog (Drosophila)
chr17_-_48450532 0.959 NM_016504
MRPL27
mitochondrial ribosomal protein L27
chr1_+_162467594 0.955 NM_144624
NM_175866
UHMK1

U2AF homology motif (UHM) kinase 1

chr9_+_131218426 0.954 ODF2
outer dense fiber of sperm tails 2
chr20_-_3766905 0.951 NM_001810
CENPB
centromere protein B, 80kDa
chr2_-_45236521 0.950 NM_016932
SIX2
SIX homeobox 2
chr22_+_38864015 0.947 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr6_+_33359620 0.944 KIFC1
kinesin family member C1
chr6_+_33359604 0.944 KIFC1
kinesin family member C1
chr9_+_120466607 0.942 TLR4
toll-like receptor 4
chr5_-_140070888 0.940 HARS
histidyl-tRNA synthetase
chr3_+_178866124 0.940 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr8_+_38034296 0.939 BAG4
BCL2-associated athanogene 4
chr6_-_30585016 0.937 NM_002714
PPP1R10
protein phosphatase 1, regulatory subunit 10
chr5_-_171433605 0.935 FBXW11
F-box and WD repeat domain containing 11
chr11_+_35684418 0.935 TRIM44
tripartite motif containing 44
chr9_-_139258240 0.934 NM_001080849
DNLZ
DNL-type zinc finger
chr20_-_2821245 0.927 NM_022760
FAM113A
family with sequence similarity 113, member A
chr5_+_147763541 0.924 NM_030793
NM_205836
FBXO38

F-box protein 38

chr3_-_178789535 0.924 ZMAT3
zinc finger, matrin-type 3
chr19_-_18391440 0.919


chr20_-_44485953 0.916 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr5_-_172755195 0.913 STC2
stanniocalcin 2
chr20_-_2821120 0.910 FAM113A
family with sequence similarity 113, member A
chr3_-_52008012 0.909 ABHD14B
abhydrolase domain containing 14B
chr5_+_67511578 0.908 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr19_-_59031167 0.908 ZBTB45
zinc finger and BTB domain containing 45
chr17_-_47022095 0.907 NM_007241
SNF8
SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
chr19_-_3062191 0.907 NM_001130
NM_198970
AES

amino-terminal enhancer of split

chr19_+_51226638 0.906 CLEC11A
C-type lectin domain family 11, member A
chr2_+_74153987 0.904 DGUOK
deoxyguanosine kinase
chr21_+_45432202 0.902 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr2_-_101767714 0.901 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr3_-_178789597 0.898 NM_022470
NM_152240
ZMAT3

zinc finger, matrin-type 3

chr5_+_140044383 0.897 NM_017706
WDR55
WD repeat domain 55
chr2_+_28113612 0.894 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_-_239148626 0.893 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr3_-_128879873 0.892 NM_001204890
NM_001199469
NM_020701
ISY1-RAB43
ISY1

ISY1-RAB43 readthrough
ISY1 splicing factor homolog (S. cerevisiae)

chr14_-_77923888 0.887 NM_001193314
NM_001193315
NM_001193316
NM_001193317
NM_022067
C14orf133




chromosome 14 open reading frame 133




chr5_+_140044457 0.886 WDR55
WD repeat domain 55
chr5_-_147763345 0.886


chr1_+_22379119 0.885 NM_001039802
NM_001791
NM_044472
CDC42


cell division cycle 42 (GTP binding protein, 25kDa)


chrX_+_55478537 0.883 NM_014061
MAGEH1
melanoma antigen family H, 1
chr9_+_131218435 0.883 ODF2
outer dense fiber of sperm tails 2
chr5_+_140071141 0.882 HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr19_+_15218141 0.882 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr4_-_39640461 0.882 NM_174921
C4orf34
chromosome 4 open reading frame 34
chr12_-_53715036 0.881 AAAS
achalasia, adrenocortical insufficiency, alacrimia
chr11_-_62389571 0.881 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr5_-_153418419 0.878 NM_018691
FAM114A2
family with sequence similarity 114, member A2
chr11_-_65655837 0.877 NM_004214
NM_198897
FIBP

fibroblast growth factor (acidic) intracellular binding protein

chr2_-_99224868 0.875 NM_001008215
COA5
cytochrome C oxidase assembly factor 5
chr5_-_137089990 0.872 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr16_+_31044849 0.869 STX4
syntaxin 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 4.14e-33 GO:0044260 cellular macromolecule metabolic process
1.43 1.17e-26 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.47 1.05e-24 GO:0090304 nucleic acid metabolic process
1.28 2.33e-24 GO:0043170 macromolecule metabolic process
1.23 2.77e-23 GO:0044237 cellular metabolic process
1.95 6.76e-21 GO:0016071 mRNA metabolic process
1.49 1.24e-20 GO:0016070 RNA metabolic process
1.32 1.65e-20 GO:0071840 cellular component organization or biogenesis
1.33 2.77e-19 GO:0034641 cellular nitrogen compound metabolic process
1.37 2.86e-19 GO:0071841 cellular component organization or biogenesis at cellular level
1.32 2.00e-18 GO:0006807 nitrogen compound metabolic process
2.48 2.37e-18 GO:0000375 RNA splicing, via transesterification reactions
2.19 2.94e-18 GO:0008380 RNA splicing
2.49 3.20e-18 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.49 3.20e-18 GO:0000398 nuclear mRNA splicing, via spliceosome
1.31 4.75e-18 GO:0016043 cellular component organization
1.70 2.73e-17 GO:0046907 intracellular transport
1.37 3.07e-17 GO:0044267 cellular protein metabolic process
1.36 3.78e-17 GO:0071842 cellular component organization at cellular level
1.43 3.83e-16 GO:0010467 gene expression
1.95 1.09e-15 GO:0016032 viral reproduction
1.95 1.04e-14 GO:0006397 mRNA processing
1.44 1.82e-14 GO:0006996 organelle organization
1.18 4.02e-14 GO:0044238 primary metabolic process
1.16 8.26e-14 GO:0008152 metabolic process
1.28 1.27e-13 GO:0060255 regulation of macromolecule metabolic process
1.61 2.02e-13 GO:0033554 cellular response to stress
1.70 2.07e-13 GO:0006396 RNA processing
1.77 6.40e-13 GO:0006974 response to DNA damage stimulus
1.51 1.29e-12 GO:0008104 protein localization
1.09 2.16e-12 GO:0009987 cellular process
1.45 3.56e-12 GO:0033036 macromolecule localization
1.57 3.96e-12 GO:0015031 protein transport
1.52 5.68e-12 GO:0007049 cell cycle
1.46 6.09e-12 GO:0051641 cellular localization
1.56 6.47e-12 GO:0045184 establishment of protein localization
1.23 6.96e-12 GO:0019222 regulation of metabolic process
1.24 4.01e-11 GO:0031323 regulation of cellular metabolic process
1.47 9.60e-11 GO:0051649 establishment of localization in cell
1.24 1.07e-10 GO:0080090 regulation of primary metabolic process
1.64 1.55e-10 GO:0009057 macromolecule catabolic process
1.69 2.38e-10 GO:0044265 cellular macromolecule catabolic process
1.45 4.47e-10 GO:0044248 cellular catabolic process
1.35 3.52e-09 GO:0009059 macromolecule biosynthetic process
1.25 3.72e-09 GO:0019538 protein metabolic process
1.82 4.77e-09 GO:0070647 protein modification by small protein conjugation or removal
1.84 1.07e-08 GO:0006412 translation
1.34 1.10e-08 GO:0034645 cellular macromolecule biosynthetic process
1.66 1.44e-08 GO:0034621 cellular macromolecular complex subunit organization
2.00 2.39e-08 GO:0000075 cell cycle checkpoint
1.36 3.26e-08 GO:0009056 catabolic process
1.97 3.88e-08 GO:0071156 regulation of cell cycle arrest
2.24 6.13e-08 GO:0048193 Golgi vesicle transport
1.85 8.40e-08 GO:0032446 protein modification by small protein conjugation
1.26 9.02e-08 GO:0010468 regulation of gene expression
1.75 9.20e-08 GO:0010564 regulation of cell cycle process
2.36 1.15e-07 GO:0032984 macromolecular complex disassembly
2.36 1.15e-07 GO:0034623 cellular macromolecular complex disassembly
1.47 2.18e-07 GO:0043933 macromolecular complex subunit organization
1.57 2.34e-07 GO:0000278 mitotic cell cycle
1.47 2.52e-07 GO:0022402 cell cycle process
2.51 2.57e-07 GO:0006415 translational termination
2.42 3.45e-07 GO:0043241 protein complex disassembly
2.42 3.45e-07 GO:0043624 cellular protein complex disassembly
1.85 3.73e-07 GO:0016567 protein ubiquitination
1.71 4.52e-07 GO:0030163 protein catabolic process
1.74 4.59e-07 GO:0051603 proteolysis involved in cellular protein catabolic process
1.53 7.96e-07 GO:0051726 regulation of cell cycle
1.72 8.12e-07 GO:0044257 cellular protein catabolic process
1.75 1.02e-06 GO:0006511 ubiquitin-dependent protein catabolic process
1.95 1.05e-06 GO:0022613 ribonucleoprotein complex biogenesis
1.49 1.65e-06 GO:0022403 cell cycle phase
1.73 1.80e-06 GO:0019941 modification-dependent protein catabolic process
1.46 2.69e-06 GO:0016192 vesicle-mediated transport
1.72 2.82e-06 GO:0043632 modification-dependent macromolecule catabolic process
1.90 2.90e-06 GO:0071843 cellular component biogenesis at cellular level
2.25 3.60e-06 GO:0000077 DNA damage checkpoint
2.43 4.04e-06 GO:0019080 viral genome expression
2.43 4.04e-06 GO:0019083 viral transcription
2.40 4.36e-06 GO:0071826 ribonucleoprotein complex subunit organization
1.22 4.88e-06 GO:0051171 regulation of nitrogen compound metabolic process
2.29 5.23e-06 GO:0006414 translational elongation
2.43 6.09e-06 GO:0022618 ribonucleoprotein complex assembly
1.24 6.50e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.26 1.26e-05 GO:0043412 macromolecule modification
2.16 1.77e-05 GO:0031570 DNA integrity checkpoint
1.98 1.79e-05 GO:0022415 viral reproductive process
1.74 1.97e-05 GO:0010608 posttranscriptional regulation of gene expression
1.23 2.04e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.37 2.12e-05 GO:0032268 regulation of cellular protein metabolic process
1.11 2.17e-05 GO:0050794 regulation of cellular process
1.27 2.38e-05 GO:0006464 protein modification process
1.53 2.66e-05 GO:0070727 cellular macromolecule localization
1.49 2.89e-05 GO:0071822 protein complex subunit organization
1.53 3.01e-05 GO:0034613 cellular protein localization
2.08 3.30e-05 GO:0007093 mitotic cell cycle checkpoint
1.37 3.77e-05 GO:0032774 RNA biosynthetic process
2.34 3.81e-05 GO:2000045 regulation of G1/S transition of mitotic cell cycle
1.35 3.98e-05 GO:0051246 regulation of protein metabolic process
1.87 4.31e-05 GO:0022411 cellular component disassembly
1.87 4.31e-05 GO:0071845 cellular component disassembly at cellular level
1.68 5.14e-05 GO:0051329 interphase of mitotic cell cycle
1.72 5.46e-05 GO:0007346 regulation of mitotic cell cycle
1.11 6.09e-05 GO:0050789 regulation of biological process
1.68 6.34e-05 GO:0048285 organelle fission
1.67 6.93e-05 GO:0051325 interphase
2.34 8.69e-05 GO:0031575 mitotic cell cycle G1/S transition checkpoint
2.34 8.69e-05 GO:0071779 G1/S transition checkpoint
2.24 9.52e-05 GO:0051438 regulation of ubiquitin-protein ligase activity
1.21 1.02e-04 GO:0031326 regulation of cellular biosynthetic process
1.23 1.03e-04 GO:0051252 regulation of RNA metabolic process
1.20 1.09e-04 GO:0009889 regulation of biosynthetic process
1.92 1.29e-04 GO:0010498 proteasomal protein catabolic process
1.92 1.29e-04 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.62 1.29e-04 GO:0006281 DNA repair
1.21 1.39e-04 GO:0009058 biosynthetic process
2.19 1.42e-04 GO:0051340 regulation of ligase activity
1.22 1.70e-04 GO:0044249 cellular biosynthetic process
2.31 2.06e-04 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.28 2.11e-04 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
1.65 2.24e-04 GO:0000087 M phase of mitotic cell cycle
1.46 2.31e-04 GO:0006259 DNA metabolic process
1.20 2.41e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.57 2.47e-04 GO:0006886 intracellular protein transport
2.28 3.19e-04 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.69 3.62e-04 GO:0009166 nucleotide catabolic process
1.31 3.66e-04 GO:0044085 cellular component biogenesis
1.58 3.90e-04 GO:0044419 interspecies interaction between organisms
1.65 3.92e-04 GO:0000280 nuclear division
1.65 3.92e-04 GO:0007067 mitosis
2.38 4.31e-04 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.95 4.51e-04 GO:0019058 viral infectious cycle
2.34 4.53e-04 GO:0051352 negative regulation of ligase activity
2.34 4.53e-04 GO:0051444 negative regulation of ubiquitin-protein ligase activity
2.23 4.90e-04 GO:0051351 positive regulation of ligase activity
1.73 5.95e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.58 6.73e-04 GO:0051301 cell division
2.34 6.84e-04 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.31 7.10e-04 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.04 7.86e-04 GO:0000084 S phase of mitotic cell cycle
1.69 9.07e-04 GO:0006195 purine nucleotide catabolic process
2.22 1.11e-03 GO:0000216 M/G1 transition of mitotic cell cycle
1.50 1.33e-03 GO:0016044 cellular membrane organization
1.99 1.42e-03 GO:0051640 organelle localization
2.38 1.49e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.38 1.49e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
2.38 1.49e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.38 1.49e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.38 1.49e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.38 1.49e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
2.38 1.49e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.38 1.49e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
1.67 1.51e-03 GO:0072523 purine-containing compound catabolic process
2.00 1.52e-03 GO:0051320 S phase
2.34 1.57e-03 GO:0071158 positive regulation of cell cycle arrest
1.70 1.63e-03 GO:0009261 ribonucleotide catabolic process
1.49 1.80e-03 GO:0061024 membrane organization
1.49 2.51e-03 GO:0000279 M phase
1.70 3.22e-03 GO:0033365 protein localization to organelle
2.10 3.35e-03 GO:0031397 negative regulation of protein ubiquitination
1.27 3.50e-03 GO:0035556 intracellular signal transduction
1.68 4.39e-03 GO:0009203 ribonucleoside triphosphate catabolic process
1.68 4.39e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.97 4.54e-03 GO:0042770 signal transduction in response to DNA damage
2.84 4.66e-03 GO:0000245 spliceosome assembly
1.67 4.81e-03 GO:0009143 nucleoside triphosphate catabolic process
1.67 4.81e-03 GO:0009154 purine ribonucleotide catabolic process
2.11 5.21e-03 GO:0051656 establishment of organelle localization
1.67 5.42e-03 GO:0009146 purine nucleoside triphosphate catabolic process
2.18 5.67e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.08 5.96e-03 GO:0065007 biological regulation
1.59 6.15e-03 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.59 6.15e-03 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
1.20 6.74e-03 GO:0006355 regulation of transcription, DNA-dependent
1.37 6.84e-03 GO:0065003 macromolecular complex assembly
2.07 7.12e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
1.18 8.31e-03 GO:0048522 positive regulation of cellular process
1.90 9.41e-03 GO:0031018 endocrine pancreas development
1.51 1.02e-02 GO:0016568 chromatin modification
1.27 1.12e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.72 1.28e-02 GO:0051169 nuclear transport
1.80 1.52e-02 GO:0031016 pancreas development
1.48 1.59e-02 GO:0007264 small GTPase mediated signal transduction
1.38 1.66e-02 GO:0051276 chromosome organization
1.71 1.79e-02 GO:0006913 nucleocytoplasmic transport
2.39 1.80e-02 GO:0050434 positive regulation of viral transcription
2.81 1.97e-02 GO:0000387 spliceosomal snRNP assembly
2.81 1.97e-02 GO:0006903 vesicle targeting
1.32 2.47e-02 GO:0031399 regulation of protein modification process
1.28 2.56e-02 GO:0022607 cellular component assembly
2.09 2.61e-02 GO:0000209 protein polyubiquitination
2.30 2.95e-02 GO:0006521 regulation of cellular amino acid metabolic process
3.68 3.15e-02 GO:0006376 mRNA splice site selection
1.76 3.16e-02 GO:0031396 regulation of protein ubiquitination
1.57 3.17e-02 GO:0051248 negative regulation of protein metabolic process
1.25 3.30e-02 GO:0009893 positive regulation of metabolic process
1.47 3.69e-02 GO:0034622 cellular macromolecular complex assembly
1.58 3.83e-02 GO:0032269 negative regulation of cellular protein metabolic process
2.45 3.85e-02 GO:0006369 termination of RNA polymerase II transcription
1.52 3.85e-02 GO:0009141 nucleoside triphosphate metabolic process
1.86 4.20e-02 GO:0031398 positive regulation of protein ubiquitination
1.75 4.47e-02 GO:0000082 G1/S transition of mitotic cell cycle
2.19 4.48e-02 GO:0006368 transcription elongation from RNA polymerase II promoter
1.87 4.62e-02 GO:0090068 positive regulation of cell cycle process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 1.76e-86 GO:0005622 intracellular
1.21 1.18e-83 GO:0044424 intracellular part
1.22 3.91e-57 GO:0043229 intracellular organelle
1.22 8.88e-57 GO:0043226 organelle
1.24 1.72e-55 GO:0043227 membrane-bounded organelle
1.24 3.35e-55 GO:0043231 intracellular membrane-bounded organelle
1.35 1.46e-51 GO:0005634 nucleus
2.20 1.33e-34 GO:0030529 ribonucleoprotein complex
1.20 2.56e-33 GO:0005737 cytoplasm
1.37 1.85e-29 GO:0032991 macromolecular complex
1.49 5.81e-28 GO:0044428 nuclear part
1.25 4.60e-24 GO:0044446 intracellular organelle part
1.46 5.57e-24 GO:0005829 cytosol
1.49 2.05e-23 GO:0031981 nuclear lumen
1.24 3.86e-23 GO:0044422 organelle part
1.42 2.79e-22 GO:0031974 membrane-enclosed lumen
1.42 2.19e-21 GO:0070013 intracellular organelle lumen
1.41 8.27e-21 GO:0043233 organelle lumen
1.55 1.98e-20 GO:0005654 nucleoplasm
1.21 3.77e-20 GO:0044444 cytoplasmic part
2.48 5.95e-13 GO:0005681 spliceosomal complex
1.29 1.91e-12 GO:0043228 non-membrane-bounded organelle
1.29 1.91e-12 GO:0043232 intracellular non-membrane-bounded organelle
2.16 4.91e-11 GO:0005840 ribosome
1.26 6.25e-11 GO:0043234 protein complex
1.55 2.03e-10 GO:0044451 nucleoplasm part
1.97 2.85e-09 GO:0016604 nuclear body
2.67 3.92e-09 GO:0071013 catalytic step 2 spliceosome
1.04 4.06e-07 GO:0005623 cell
1.04 5.43e-07 GO:0044464 cell part
2.03 5.66e-07 GO:0044445 cytosolic part
2.07 1.25e-05 GO:0016607 nuclear speck
3.17 2.57e-05 GO:0030532 small nuclear ribonucleoprotein complex
1.29 4.51e-05 GO:0005739 mitochondrion
1.59 6.72e-05 GO:0005815 microtubule organizing center
1.41 9.00e-05 GO:0015630 microtubule cytoskeleton
2.28 1.24e-04 GO:0022626 cytosolic ribosome
1.89 2.28e-04 GO:0000151 ubiquitin ligase complex
2.38 2.54e-04 GO:0015934 large ribosomal subunit
3.26 6.48e-04 GO:0005689 U12-type spliceosomal complex
2.20 2.23e-03 GO:0030117 membrane coat
2.20 2.23e-03 GO:0048475 coated membrane
2.23 2.24e-03 GO:0000502 proteasome complex
1.44 2.24e-03 GO:0005768 endosome
1.41 2.57e-03 GO:0005730 nucleolus
2.06 2.70e-03 GO:0000790 nuclear chromatin
1.41 7.13e-03 GO:0044427 chromosomal part
1.89 9.50e-03 GO:0005925 focal adhesion
1.65 9.58e-03 GO:0005819 spindle
1.36 1.35e-02 GO:0005694 chromosome
1.32 1.79e-02 GO:0044429 mitochondrial part
1.56 1.81e-02 GO:0005813 centrosome
3.83 2.23e-02 GO:0005732 small nucleolar ribonucleoprotein complex
1.52 2.43e-02 GO:0010008 endosome membrane
1.50 3.33e-02 GO:0044440 endosomal part
2.48 3.50e-02 GO:0022627 cytosolic small ribosomal subunit
1.80 3.64e-02 GO:0005924 cell-substrate adherens junction
1.78 4.19e-02 GO:0030055 cell-substrate junction
1.54 4.91e-02 GO:0000228 nuclear chromosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 2.59e-33 GO:0005515 protein binding
1.12 9.82e-31 GO:0005488 binding
1.34 3.65e-23 GO:0003676 nucleic acid binding
1.67 5.92e-18 GO:0003723 RNA binding
2.20 4.84e-09 GO:0003735 structural constituent of ribosome
1.28 4.62e-08 GO:0008270 zinc ion binding
1.24 1.31e-06 GO:0003677 DNA binding
1.22 4.05e-05 GO:0046914 transition metal ion binding
1.38 2.44e-04 GO:0019899 enzyme binding
1.65 9.55e-04 GO:0019787 small conjugating protein ligase activity
1.49 2.22e-03 GO:0000988 protein binding transcription factor activity
1.49 2.22e-03 GO:0000989 transcription factor binding transcription factor activity
1.64 2.59e-03 GO:0004842 ubiquitin-protein ligase activity
1.48 3.36e-03 GO:0003712 transcription cofactor activity
1.56 5.13e-03 GO:0016881 acid-amino acid ligase activity
1.52 8.13e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.60 1.04e-02 GO:0003713 transcription coactivator activity
1.17 1.48e-02 GO:0000166 nucleotide binding
1.12 1.98e-02 GO:0046872 metal ion binding
1.11 4.33e-02 GO:0043167 ion binding